Biopharmaceutical firm Attralus has completed a $25 million Series A financing designed to further validate its AT-01 pan-amyloid radiotracer for PET/CT. Led by venBio Partners, the infusion is also intended to advance two therapeutic candidates, AT-02 and AT-03, into clinical development for ATTR (transthyretin), AL (light chain), and potentially, ALECT 2 systemic amyloidosis. Amyloidosis is
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Contrast-enhanced ultrasound (CEUS) helps physicians accurately diagnose some forms of liver cancer more safely and less expensively than computed tomography (CT) and magnetic resonance (MR), according to a report  published earlier this month in Hepatoma Research. CEUS shows “comparable performance with CT and MR for liver mass characterization and prediction of malignancy,” lead author Stephanie
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The FDA has granted RadLogics 510(k) clearance for its AI-Powered chest x-ray pneumothorax application, the company announced Tuesday. Operating in tandem with existing workflow applications, the application, which is trained via pattern recognition, leverages an AI algorithm to analyze images for features that suggest the presence of pneumothorax. It then makes case-level output available to
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In addition, among women with high socioeconomic status, 11.7% of Black women experienced delays in initiating treatment. Far fewer white women in this group (6.7%) were noted to have had the same. “Even among women with low socioeconomic status, we still saw fewer delays among white women, underscoring the disparate experience of Black women, who
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Overall, the algorithm predicted osteoarthritis with 78% accuracy from MRIs performed three years before symptom onset, picking up signs of the disease that are too subtle to register in radiologists’ eyes. Currently, there are no drugs that prevent presymptomatic osteoarthritis from developing into full-blown joint deterioration, but drugs that can prevent patients from developing a
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All studies were evaluated for arterial or venous thromboembolism, the presence of which, when identified, was confirmed by two abdominal radiologists. Patients’ EMRs were reviewed for inflammatory markers, hospital course and, in those with thromboembolic findings, other hypercoagulability risk factors. Thromboembolic findings were discovered in nine patients (11%) with COVID-19; of these patients, five had
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At the 56th annual European Association for the Study of Diabetes (EASD) 2020 meeting, positive results were presented for Novo Nordisk’s insulin icodec in direct comparison to insulin glargine U100. Insulin icodec, currently in Phase II trials, demonstrated comparable efficacy and safety to once-daily-administered insulin glargine U100 in patients who have not previously been prescribed
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Vifor Pharma has reported data from the AFFIRM-AHF clinical trial of Ferinject (intravenous ferric carboxymaltose) in iron-deficient patients hospitalised due to acute heart failure (AHF). The trial did not reach statistical significance on its composite primary endpoint of decreasing the risk of total heart failure hospitalisations and cardiovascular death. Ferinject is a non-dextran-based intravenous iron
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Following a review of data from the Phase I STRONG study of the intrathecal (IT) formulation of Novartis’ one-off gene therapy Zolgensma (onasemnogene abeparvovec) in older patients with spinal muscular atrophy (SMA), the FDA has requested a pivotal Phase III confirmatory study to further support the drug’s regulatory filing. Clinical data from the new study
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US-based biotechnology firm Novavax has started the first Phase III clinical trial of its potential Covid-19 vaccine, NVX-CoV2373, in the UK. Performed in collaboration with the UK Government’s Vaccines Taskforce, the trial will investigate the safety, efficacy and immunogenicity of NVX-CoV2373. The study is designed to recruit up to 10,000 participants aged 18 to 84
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At the 56th annual European Association for the Study of Diabetes (EASD) 2020 meeting, positive results have been discussed for the novel oral hypoglycemic drug imeglimin, which is currently under development for the treatment of type 2 diabetes (T2D). The drug is of a novel structure and mechanism, establishing imeglimin as a first-in-class for the
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25 September Global: The global Covid-19 death toll passed 983,000 on Friday, according to the Johns Hopkins University tracker. With the number of deaths confirmed daily averaging more than 5,000, it looks likely the toll will pass one million within days. There are 32.2 million Covid-19 cases worldwide. The virus is continuing to mutate throughout
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