Clinical Trials & Research

At the 56th annual European Association for the Study of Diabetes (EASD) 2020 meeting, positive results were presented for Novo Nordisk’s insulin icodec in direct comparison to insulin glargine U100. Insulin icodec, currently in Phase II trials, demonstrated comparable efficacy and safety to once-daily-administered insulin glargine U100 in patients who have not previously been prescribed
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Vifor Pharma has reported data from the AFFIRM-AHF clinical trial of Ferinject (intravenous ferric carboxymaltose) in iron-deficient patients hospitalised due to acute heart failure (AHF). The trial did not reach statistical significance on its composite primary endpoint of decreasing the risk of total heart failure hospitalisations and cardiovascular death. Ferinject is a non-dextran-based intravenous iron
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Following a review of data from the Phase I STRONG study of the intrathecal (IT) formulation of Novartis’ one-off gene therapy Zolgensma (onasemnogene abeparvovec) in older patients with spinal muscular atrophy (SMA), the FDA has requested a pivotal Phase III confirmatory study to further support the drug’s regulatory filing. Clinical data from the new study
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US-based biotechnology firm Novavax has started the first Phase III clinical trial of its potential Covid-19 vaccine, NVX-CoV2373, in the UK. Performed in collaboration with the UK Government’s Vaccines Taskforce, the trial will investigate the safety, efficacy and immunogenicity of NVX-CoV2373. The study is designed to recruit up to 10,000 participants aged 18 to 84
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At the 56th annual European Association for the Study of Diabetes (EASD) 2020 meeting, positive results have been discussed for the novel oral hypoglycemic drug imeglimin, which is currently under development for the treatment of type 2 diabetes (T2D). The drug is of a novel structure and mechanism, establishing imeglimin as a first-in-class for the
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25 September Global: The global Covid-19 death toll passed 983,000 on Friday, according to the Johns Hopkins University tracker. With the number of deaths confirmed daily averaging more than 5,000, it looks likely the toll will pass one million within days. There are 32.2 million Covid-19 cases worldwide. The virus is continuing to mutate throughout
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25 September Globally, the total confirmed cases of Covid-19 have reached over 32,273,000 with more than 983,000 deaths and 22,255,000 recoveries. The US, India and Brazil remain top three worst-hit countries. The US will soon reach 7 million total confirmed cases of Covid-19. After several weeks seeing an overall downward trend in new cases, the
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Marinus Pharmaceuticals is set to start patient enrolment in the Phase III RAISE clinical trial of ganaxolone for the treatment of refractory status epilepticus (RSE). The announcement comes after the company satisfied the US Food and Drug Administration (FDA)’s protocol-specific questions for the trial. Marinus develops treatments for rare seizure disorders. In July, the company
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Reviewed by Emily Henderson, B.Sc.Sep 25 2020 Emergency departments of hospitals generate significant amounts of environmentally harmful waste which could be reduced through basic changes to disposal policies and practices, while producing lower operating costs, researchers from Massachusetts General Hospital (MGH) have found. Efforts to optimize the daily waste stream through improvements such as switching
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Reviewed by Emily Henderson, B.Sc.Sep 25 2020 Fragile gains made to advance women and children’s health are threatened by conflict, the climate crisis and COVID-19, according to a new report from Every Woman Every Child. Protect the Progress: Rise, Refocus, Recover, 2020 highlights that since the Every Woman Every Child movement was launched 10 years
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Reviewed by Emily Henderson, B.Sc.Sep 25 2020 A new Viewpoint piece published online in the Annals of the American Thoracic Society examines the ways in which COVID-19 disproportionately impacts historically disadvantaged communities of color in the United States, and how baseline inequalities in our health system are amplified by the pandemic. The authors also discuss
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Reviewed by Emily Henderson, B.Sc.Sep 25 2020 Being traumatized can cause what are known as dissociative symptoms–such as experiencing amnesia, an out-of-body experience, feeling emotionally numb–which may help people cope. Experiencing these symptoms intensely or for a long time, however, can negatively impact an individual’s ability to function. A team led by investigators at McLean
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Reviewed by Emily Henderson, B.Sc.Sep 25 2020 Clostridioides difficile, or C. diff, is the leading cause of health care-associated infection in the U.S. Only two antibiotics, vancomycin and fidaxomicin, are FDA approved for the treatment of C. diff, but even these therapies suffer from high treatment failure and recurrence. Now, Purdue University innovators have advanced
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Sep 25 2020 The importance of cleanrooms is currently in the spotlight as the global community awaits a vaccine for Covid-19. Laboratories need controlled environments that are contamination free in order to carry out development and testing that produces reliable test results. [embedded content] A cleanroom is classified according to the level of cleanliness of
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