Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury – Lu L, Li F, Wang P, Chen H, Chen YC, Yin X.

Medical and Health News

BACKGROUND: Submit-traumatic headache (PTH) is likely one of the most frequent signs following mild traumatic brain injury (mTBI). Neuroimaging research implicate hypothalamic perform connectivity (FC) disruption as an vital issue in ache issues. Nevertheless…

Supply: SafetyLit Class: Worldwide Drugs & Public Well being Tags: Economics of Injury and Security, PTSD, Injury Outcomes Supply Sort: information

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AbstractBackgroundPost-traumatic headache (PTH) is likely one of the most frequent signs following mild traumatic brain injury (mTBI). Neuroimaging research implicate hypothalamic perform connectivity (FC) disruption as an vital issue in ache issues. Nevertheless, it’s unknown whether or not there are alterations in the hypothalamus-based mostly resting state FC inside PTH following mTBI on the acute stage and its relationship with headache symptom measurement.MethodsForty-4 mTBI sufferers with PTH, 27 mTBI sufferers with out PTH and 43 wholesome controls who had been nicely matched for age, gender, and years of training had been enrolled in this …

ConclusionAt current, regardless of its excessive prevalence, PTH just isn’t fully understood, and the differential contribution of pathophysiological mechanisms, additionally noticed in different circumstances like migraine, needs to be clarified. Though dealing with limitations, animal fashions are wanted to enhance understanding of PTH. The data of presently obtainable fashions is critical to all researchers who need to examine PTH and contribute to unravel its mechanisms.

AbstractPurpose of ReviewTo talk about latest literature in regards to the software of the biopsychosocial mannequin in the administration of concussion and publish-concussion headache.Current FindingsCurrent analysis means that the biopsychosocial mannequin is relevant to the concussion administration course of, notably administration of publish-concussion headache. Such software is finest illustrated by present energetic remedy methods equivalent to train, multifaceted rehabilitation, and psychosocial interventions concentrating on improved affected person outcomes.SummaryOverall, the biopsychosocial mannequin has vital purposes to the administration of …

AbstractAn rising variety of sufferers with persistent persistent post-traumatic headache (PPTH) after mild traumatic brain injury (MTBI) are being referred to headache or ache specialists as standard remedy choices for main headache issues haven’t been capable of adequately alleviate their debilitating headache signs. Evolving scientific and mechanistic evidences assist the notation that persistent persistent MTBI associated complications (MTBI-HA) carry the hallmark traits of neuropathic ache. Thus, in addition to traditional remedy choices relevant to non-traumatic main headache issues, different avai…

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Submit-traumatic headache (PTH) could also be thought-about a secondary headache, which is linked to extreme incapacity and psychosocial impairment. Apparently, practically 30% of topics with persistent post-traumatic headache (PPTH) additionally undergo from post-traumatic stress dysfunction (PTSD). Though present research demonstrated the existence of frequent pathophysiological traits in topics with migraine and PPTH, the variations and similarities between these advanced illnesses are presently poorly understood and are but to be comprehensively elucidated. Thus, the current overview aimed to systematically examine the …

ConclusionsAmong sufferers with persistent PTH, erenumab resulted in a decrease frequency of average to extreme headache days in this 12-week open-label trial. As well as, erenumab was nicely-tolerated as discontinuations on account of adversarial occasions had been low. Placebo-managed randomized scientific trials are wanted to adequately consider the efficacy and security of erenumab in sufferers with  persistent PTH.Trial registrationClinicalTrials.Gov,NCT03974360. Registered on April 17, 2019 – Retrospectively registered

ConclusionNotwithstanding some phenotypic similarities, persistent post-traumatic headache after traumatic brain injury, is taken into account a separate phenomenon from migraine however obtainable information is inconclusive. Excessive-high quality research are additional required to analyze the pathophysiological mechanisms of this secondary headache, in order to establish new targets for remedy and to stop incapacity.

Headache issues are extremely prevalent and debilitating, with restricted remedy choices. Earlier research point out that many proinflammatory immune cells contribute to headache pathophysiology. Given the nicely-acknowledged function of regulatory T (Treg) cells in sustaining immune homeostasis, we hypothesized that enhancing Treg perform could also be efficient to deal with a number of headache issues. In a mouse mannequin of persistent migraine, we noticed that repeated nitroglycerin (NTG, a dependable set off of migraine in sufferers) administration doubled the variety of CD3+ T cells in the trigeminal ganglia with out altering the variety of Treg …

Supply: Pain Class: Anesthesiology Tags: Analysis Paper Supply Sort: analysis

Cassidy JD
Summary
IMPORTANCE: The prognosis of post-traumatic headache is poorly understood.
OBJECTIVE: To develop and validate a prognostic mannequin to foretell the presence of post-traumatic headache six months after a site visitors collision in adults with incident post-traumatic headache.
DESIGN: Secondary analyses of adults with incident post-traumatic headache injured in site visitors collisions between November 1997 and December 1999 in Saskatchewan, Canada (improvement cohort); and between January 2004 and January 2005 in Sweden (validation cohort).
SETTING: The Saskatchewan cohort (improvement) was popul…

Supply: Accident; Analysis and Prevention. Class: Accident Prevention Authors: Tags: Accid Anal Prev Supply Sort: analysis

CONCLUSIONS: We discovered that there’s little proof for any threat components concerned in the event of acute PTH, whereas no research had assessed threat components for the event of persistent PTH. Additional research are warranted and must be powered to look at doable threat components for the event of PTH. Rigorous methodology and standardized monitoring must be prioritized to assist excessive-high quality analysis and validate potential findings.
PMID: 32320055 [PubMed – as supplied by publisher]

Supply: Headache Class: Neurology Authors: Tags: Headache Supply Sort: analysis

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