Marcel Leist, Professor of In-Vitro Toxicology and Biomedicine on the College of Konstanz, and Thomas Hartung, Professor of Environmental Well being Sciences on the College of Konstanz and Doerenkamp-Zbinden Chair of Proof-Based mostly Toxicology at Johns Hopkins Bloomberg College of Public Well being in Baltimore, have been awarded the Ursula M. Händel Animal Welfare Prize 2020 of the German Analysis Basis (DFG).
That is the second time inside a interval of ten years that College of Konstanz researchers have been awarded the distinguished accolade, earlier recipients together with molecular toxicologists Professor Alexander Bürkle and Dr Moreno-Villanueva, additionally primarily based on the College of Konstanzʼs Division of Biology, who acquired the prize in 2011.
The Ursula M. Händel Animal Welfare Prize, which is endowed with 80,000 euros, acknowledges scientists who’ve made exemplary and sustained efforts to enhance the welfare of animals in analysis, particularly by means of the event of processes contributing to the discount, refinement and substitute of animal experimentation in accordance with the 3R precept.
The 2020 prize can be awarded throughout an official ceremony scheduled for 1 October 2020 on the 3R-Zentrum in Gießen (ICAR3R), which can be preceded by a 3R symposium and mix on-line in addition to on-site components.
Recognition for selling animal welfare
In contrast to earlier recipients, Marcel Leist and Thomas Hartung have been chosen for his or her lifetime achievement in selling animal welfare by means of their analysis, because the DFG introduced – as an example through the use of synthetic intelligence to make inferences concerning the toxicity of unknown substances or to generate automated predictions from toxicological databases. Each approaches assist to keep away from or considerably scale back animal testing. The jury confirmed itself notably impressed with the researchersʼ enduring dedication to growing and implementing different strategies in toxicology and to elevating acceptance ranges on the native and worldwide ranges each in academia and past – particularly by means of their work as co-directors of the Heart for Options to Animal Testing in Europe (CAAT-Europe).
CAAT-Europe, a three way partnership of the College of Konstanz supported by the Doerenkamp-Zbinden Basis for animal-free analysis and the Bloomberg College of Public Well being at Johns Hopkins College, was set as much as coordinate transatlantic actions selling the event of latest and improved strategies in toxicology, to advise on technique improvement, to supply a platform for trade amongst varied stakeholders in academia, trade and politics and, above all, to assist the 3R precept of humane science.
Overcoming the validation dilemma
“I am convinced that working together across sectors is the best – and possibly only – way forward if we want to deliver the best possible outcomes for both humans and animals”, says Leist. “Promoting humane science isnʼt just a handy and politically opportune catchphrase: it is a research objective my colleagues and I are invested in deeply”. All through their careers, and since CAAT-Europe was based in 2010, each Leist and Hartung have sought to develop basic instruments to reinforce the implementation and speed up the broader use of animal-free testing strategies, together with computational approaches and novel take a look at improvement methods.
“One major issue that we seek to address through CAAT-Europe and that regulators from both sides of the Atlantic regularly confirm is insufficient method documentation and data reporting. Both are major drawbacks when it comes to using data generated through in-vitro methods”, explains Thomas Hartung. “Contributions that help resolve this dilemma can have a very broad impact on the overall use and development of alternative methods”.
Up to now many years, CAAT-Europe produced 21 prolonged critiques on particular analysis issues and gaps within the present data. Potential options have come out of its transatlantic toxicology suppose tank actions, primarily based on the enter of greater than 250 co-authors from academia, trade, regulatory our bodies and non-governmental organisations.
About Marcel Leist
Marcel Leist has been Professor of In-Vitro Toxicology and Biomedicine on the College of Konstanz since 2006, a place that was initially established and endowed by the Doerenkamp-Zbinden Basis. He studied biochemistry in Tübingen (Germany) and holds a graspʼs diploma in toxicology from the College of Surrey (1989) in addition to a doctoral diploma in pharmacology from the College of Konstanz (1993). He obtained his Habilitation (postdoctoral qualification) in toxicology/cell biology in 1998. Previous to accepting his present place at Konstanz, Marcel Leist labored for Danish pharmaceutical firm H. Lundbeck A/S in Copenhagen.
Leist has acquired a number of main animal welfare awards, together with the Lush Prize in assist of initiatives to finish or change animal testing (2016, alongside Dr Giorgia Pallocca, coordinator and deputy director of CAAT-Europe), the Animal Welfare Analysis Prize of the German Federal Ministry of Meals and Agriculture (2015) in addition to the Society of Toxicology Enhancement of Animal Welfare Award (2015).
About Thomas Hartung
Thomas Hartung has been Professor of Proof-Based mostly Toxicology at Johns Hopkins Bloomberg College of Public Well being in Baltimore since 2009 and likewise holds the place of Professor of Environmental Well being Sciences on the College of Konstanz. He studied laptop science in Hagen in addition to biochemistry and medication in Tübingen, the place he additionally earned his medical doctoral diploma in toxicology in 1992. Hartung additionally earned a organic doctoral diploma in biochemical pharmacology from the College of Konstanz. He was CEO of the Steinbeis Know-how Switch Heart for In Vitro Pharmacology and Toxicology on the College of Konstanz from 1996 to 2002 and led the European Centre for the Validation of Different Strategies of the European Fee in Ispra (Italy) from 2002 to 2008.
Thomas Hartung has gained a number of awards for his analysis within the space of animal welfare, together with the Russell and Burch Award of the Humane Society of the USA (2009) and the Society of Toxicology Enhancement of Animal Welfare Award (2007).