Using personalized precision medicine to treat cognitive decline

Clinical Trials & Research, Research and Clinical Trials

Newest analysis from Affirmativ Well being succeeds in treating cognitive decline utilizing personalized, precision medicine.

Affirmativ Well being sought to decide whether or not a complete and personalized program, designed to mitigate danger components of Alzheimer’s illness might enhance cognitive and metabolic perform in people experiencing cognitive decline. Findings offered proof that this method can enhance danger issue scores and stabilize cognitive perform.

July 31, 2020/Sonoma, CA Cognitive decline is a significant concern of the growing old inhabitants. Already, Alzheimer’s illness impacts roughly 5.four million People and 30 million individuals globally. With out efficient prevention and therapy, the prospects for the long run are bleak. By 2050, it’s estimated that 160 million individuals globally can have the illness, together with 13 million People, main to potential chapter of the Medicare system. In contrast to a number of different power diseases, Alzheimer’s illness is on the rise–recent estimates counsel that Alzheimer’s illness has develop into the third main reason behind loss of life in america behind heart problems and most cancers. Since its first description over 100 years in the past, Alzheimer’s illness has been with out efficient therapy.

Whereas researchers proceed to hunt down a remedy, it’s changing into clear that there are efficient therapy choices. Increasingly more analysis helps the conclusion that Alzheimer’s illness is just not a illness of solely Beta Amyloid plaques and Tao tangles however a posh and systemic illness. On this research of sufferers with various ranges of cognitive decline, it’s demonstrated how a precision and personalized method ends in both stabilization or enchancment in reminiscence.

Interventions to cease the development of Alzheimer’s illness have been marginally profitable at finest. This research makes use of a extra complete, personalized method addressing every participant’s distinctive danger components. “The findings, published in the Journal of Alzheimer’s Disease Reports (Journal of Alzheimer’s Disease Reports 4(1)), are encouraging and indicate that a more extensive clinical study is warranted”, mentioned Brian Kennedy, PhD, Director of The Centre for Wholesome Growing old, Nationwide College Well being System, Singapore and Chief Scientific Officer, Affirmativ Well being.

The Affirmativ Well being scientific workforce, after thorough evaluation of printed analysis, has developed a complete method to addressing scientifically supported danger components which have been rigorously outlined as interventions to promote prevention, elevated resiliency, and stabilization of mind perform within the realm of AD and dementia. Using leading edge expertise in live performance with in-person teaching and session, we’re demonstrating {that a} multi-modal and personalized method promotes an improved resiliency and restoration of optimum mind perform. The personalized therapeutic program consists of genetics, an intensive blood panel, medical historical past and life-style knowledge to consider related metabolic danger components and nutrient ranges related to cognitive well being. “Target laboratory levels differ from standard laboratory ranges as the goal is to reach optimized levels for cognitive health”, Ginger Schechter, MD, Chief Medical Officer, Affirmativ Well being

The research method considers greater than 35 components identified to contribute to cognitive decline. Outcomes reveal that sure of these components are extra affected than others once more demonstrating the necessity for a extra exact therapy plan.

This research helps the necessity for an method that focuses on a one-size matches one, not a one-size matches all, method that comprehensively assesses all concerned danger components affecting reminiscence loss.”

Denise M Kalos, CEO Affirmativ Well being

Along with the publication of this important research, and to expose various therapy choices for Alzheimer’s illness and cognitive decline, the workforce at Affirmativ Well being has written a guide, Outsmart your Mind – an Insider’s Information to Life-Lengthy Reminiscence. “Memory is not something that should diminish with age; you are never too young to start developing healthy habits that can ultimately impact your cognition,” Outsmart Your Mind. This guide leverages the inspiration of Affirmativ Well being’s analysis to ship a ideas and instruments information for the upkeep of fine cognitive well being. “Far too few people understand how critical lifestyle and dietary choices are for brain function. ‘Outsmart Your Brain’ is an important tool to get this information into the hands of those who should know it, everyone!, in easy-to-understand language”, Ryan R. Fortna, MD, PhD, Chief Medical/Scientific Officer, ADx Healthcare.

Journal reference:

Schechter, G., et al. (2020) A Complete, Multi-Modal Technique to Mitigate Alzheimer’s Illness Danger Elements Improves Facets of Metabolism and Offsets Cognitive Decline in People with Cognitive Impairment. JAD Stories. doi.org/10.3233/ADR-200185.

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